A number of my users have multiple Exchange accounts loaded in their Outlook (2010), both located on my Exchange 2010 server.  The accounts are set up as separate users with different email addresses.  All my users have their primary email address (user@primary.com) as their default account, but some have this second email address (user@secondary.com) in their Outlook that's set up as a second Exchange account in their mail profile.  All the users can use the drop-down box in the From field to change what address they are sending with.

The problem seems to be relatively random, though, where they will send an email using their secondary address and it will get stuck in their Outbox and the Send/Receive dialog box displays the error "0x8004010F: Outlook data file cannot be accessed" with their secondary account showing the error.  Mail still flows to their secondary account and both to and from their primary.

Often times simply restarting Outlook allows the message to send, and it will appear in their Sent folder.  It's happening often enough, though, that my users are complaining and since there are a fair number of them, I'm getting at least one complaint a day, and telling them to restart Outlook isn't a viable long-term solution.  So far, I have tried, without success:

1) Creating a new Outlook profile.

2) Creating a new OST for both primary and secondary accounts.

3) Setting the secondary account to not use cached mode.  My thinking was no Outlook data file, no error about it not being accessed.  No such luck.

I'm just about at my wit's end.  Previously these accounts were hosted on a 3rd party server and accessed using POP/SMTP, so bringing the accounts in-house seemed like a no-brainer, but I just cannot get them to work properly.

Does anyone have any thoughts about either what else I could try, or even a best practices of how something like this *should* be set up, other than two Exchange accounts?  Thanks.

If you want to manage multiple exchange mailbox in Outlook then you can refer the article: http://support.microsoft.com/kb/291626 and http://technet.microsoft.com/en-us/library/ee815819.aspx. If you see any errors regarding that, then you can have a look at the article: http://support.microsoft.com/kb/981245

Was there a resolution to this issue?  I have the same exact problem and cannot figure out what it needs to be.  Microsofts KB sites are all down apparently.

This shouldn't be that hard.  It seems like the exchange account will work once, then it won't.  I have a client who has multiple users that access a shared mailbox, this should not be that difficult.

Are Exchange 2010 SP2 and all rollups required?

Did you ever solve this issue?

I know this question is old, however, I just wanted to post what I did that helped me.

I had a user with the same issue, after adding both Exchange accounts, the second only seems to work once. After closing and re-opening Outlook email fails to send with the aforementioned error.

What I had to do was add the mailbox as a second mailbox on the primary Exchange account in Outlook, then in Exchange went to the secondary mailbox and gave the primary user Send As permissions to said mailbox.

They could then send and receive email as the second account. The only thing is it does not seem to allow different signatures as the signatures are mapped to an Outlook email account rather than an email address.

Hope this will help someone, even if you only use it as a workaround.

• Edited by Cory Borrow 9 hours 44 minutes ago Grammar.